Molecular Pathways: The Necrosome—A Target for Cancer Therapy
نویسندگان
چکیده
منابع مشابه
Molecular Pathways Molecular Pathways: CDK4 Inhibitors for Cancer Therapy
Unrestrained growth is the hallmark of cancer, and disrupted cell-cycle regulation is, therefore, common. CDK4 is the key regulator of the G1–S transition. In complex with cyclin D, CDK4 phosphorylates retinoblastoma protein (Rb) and drives cell-cycle progression, a process inhibited by p16. The p16– CDK4–cyclin D–Rb is aberrant in themajority of cancers and is, thus, a logical target for antic...
متن کاملMolecular pathways: CDK4 inhibitors for cancer therapy.
Unrestrained growth is the hallmark of cancer, and disrupted cell-cycle regulation is, therefore, common. CDK4 is the key regulator of the G1-S transition. In complex with cyclin D, CDK4 phosphorylates retinoblastoma protein (Rb) and drives cell-cycle progression, a process inhibited by p16. The p16-CDK4-cyclin D-Rb is aberrant in the majority of cancers and is, thus, a logical target for antic...
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The humanATR gene encodes a kinase that is activated byDNA damage and replication stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR phosphorylates multiple substrates, including the kinase Chk1, to regulate cellcycle progression, replication fork stability, andDNA repair. These events promote cell survival during replication stress and in cells with DNA damag...
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Reactive oxygen species (ROS) are important in regulating normal cellular processes, but deregulated ROS contribute to the development of various human diseases, including cancers. Cancer cells have increased ROS levels compared with normal cells, because of their accelerated metabolism. The high ROS levels in cancer cells, which distinguish them fromnormal cells, could be protumorigenic, but a...
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TGF-b is a ubiquitous cytokine that plays an active role in many cellular processes. Nearly every cell type has the ability to secrete TGF-b, as well as the ability to respond to TGF-b via the presence of TGF-b receptors on the cell surface. Consequently, gain or loss of function of the TGF-b pathway and its components are known to lead to a variety of diseases, including cancer. In epithelial ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2016
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-16-0968